Linalool odor‐induced analgesia is triggered by TRPA1-independent pathway in mice

13Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemical senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute toward triggering the linalool odor-induced analgesia, still remain unexplored. In vitro studies have shown that the transient receptor potential ankyrin 1 (TRPA1) responded to linalool, thus raising the possibility that TRPA1 expressed on the trigeminal nerve terminal detects linalool odor inhaled into the nostril and triggers the analgesic effects. To address this hypothesis, we measured the behavioral pain threshold for noxious mechanical stimulation in TRPA1-deficient mice. In contrast to our expectation, we found a significant increase in the threshold after linalool odor exposure in TRPA1-deficient mice, indicating the analgesic effects of linalool odor even in TRPA1-deficient mice. Furthermore, intranasal application of TRPA1 selective antagonist did not alter the analgesic effect of linalool odor. These results showed that the linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.

References Powered by Scopus

The capsaicin receptor: A heat-activated ion channel in the pain pathway

7740Citations
N/AReaders
Get full text

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

2125Citations
N/AReaders
Get full text

The Synaptic Organization of the Brain

1370Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Possible use of phytochemicals for recovery from covid-19-induced anosmia and ageusia

41Citations
N/AReaders
Get full text

Lavandula x intermedia—A Bastard Lavender or a Plant of Many Values? Part II. Biological Activities and Applications of Lavandin

14Citations
N/AReaders
Get full text

Comprehensive study of volatile compounds of rare Leucosceptrum canum Smith honey: Aroma profiling and characteristic compound screening via GC–MS and GC–MS/MS

13Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kashiwadani, H., Higa, Y., Sugimura, M., & Kuwaki, T. (2021). Linalool odor‐induced analgesia is triggered by TRPA1-independent pathway in mice. Behavioral and Brain Functions, 17(1). https://doi.org/10.1186/s12993-021-00176-y

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 6

60%

Researcher 3

30%

Professor / Associate Prof. 1

10%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 5

36%

Pharmacology, Toxicology and Pharmaceut... 4

29%

Medicine and Dentistry 3

21%

Nursing and Health Professions 2

14%

Save time finding and organizing research with Mendeley

Sign up for free