THIADIAZOLE AS AN ANTIMICROBIAL SCAFFOLD

Abstract

ATP6 gene represent mitochondrial gene that play important role in oxidative phosphorylation process which is important for ATP production and the occurrence of mutations in ATP6 gene and associated genes may disrupt mitochondrial oxidative phosphorylation and this correlated with a different diseases.This study attempt to detect the association between polymorphisms in ATP6 gene and vitiligo. The results showed the presence of deletion in ATP6 gene was (16%) of patients group while in control group was (5%) while the normal pattern was (84%) in patients and (95%) in control group.The deletion in ATP6 gene may associate with the loss of melanin from melanocyte in vitiligo patients and this needs more investigation.