Plewig and Kligman´s Acne and Rosacea

Abstract

This chapter provides a unifying model for acne therapy on the basis of transcriptomic regulation. Evidence from the literature will be presented that treatment-induced overexpression of the transcription factor p53, known as the guardian of the genome, is the critical effector of anti-acne therapies, which controls IGF-1 and androgen signaling, sebocyte homeostasis, and sebum production.