Carbapenem-resistant Acinetobacter baumannii producing OXA-23 in Thailand

Abstract

We investigated the resistance determinant of 13 clinical isolates of carbapenem-resistant Acinetobacter baumannii collected from a regional hospital in the north of Thailand. All isolates were multidrug resistant and produced the OXA-23 carbapenemase. The blaOXA-23 gene was found adjacent to ISAba1. Furthermore, two isolates carried the metallo β-lactamase gene, blaIMP. The blaOXA-23 and blaIMP genes were plasmid-mediated according to the transformation assays. This is the first description of OXA-23-producing A. baumannii from Thailand.