Zebrafish are increasingly used to perform phenotypic screens to identify agents that can alter physiology in a whole organismal context. Here, we describe an automated high-content chemical screen using transgenic zebrafish embryos to identify small molecules that modulate Fibroblast Growth Factor Signaling. High content multi-well screening was further refined with a particular emphasis on automated imaging and quantification that increases sensitivity and throughput of whole organism chemical screens.
CITATION STYLE
Saydmohammed, M., & Tsang, M. (2018). High-throughput automated chemical screens in zebrafish. In Methods in Molecular Biology (Vol. 1683, pp. 383–393). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7357-6_22
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