Timely removal of shed photoreceptor outer segments by retinal pigment epithelial cells (RPE) plays a key role in biological renewal of these highly peroxidizable structures and in maintenance of retina health. How environmental stress cause RPE cell dysfunction is undefined however. AMP-activated protein kinase (AMPK), a heterotrimer of a catalytic α subunit and regulatory β and γ subunits, maintains energy homeostasis by limiting energy utilization and/or promoting energy production when energy supply is compromised. Intriguingly, AMPK has been shown to be important in functions of RPE cells. In this mini-review, the role and mechanisms of AMPK in controlling RPE cell phagocytosis are discussed.
CITATION STYLE
Qin, S. (2016). Blockade of merTK activation by AMPK inhibits RPE cell phagocytosis. In Advances in Experimental Medicine and Biology (Vol. 854, pp. 773–778). Springer New York LLC. https://doi.org/10.1007/978-3-319-17121-0_103
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