Early-Onset Cerebral Amyloid Angiopathy, A Prion-Like Disease: Case Report and Literature Review

Abstract

We report the case of a 38-year-old woman who suffered repeated intracerebral hemorrhages caused by cerebral amyloid angiopathy three decades after an astrocytoma resection with cadaveric dural graft used for closing. Neuroimaging showed extensive left parenchymal hematoma, several microbleeds and frontal and occipital superficial siderosis. Pathology showed blood vessels with deposits stained with Congo Red, suggestive of cerebral amyloid angiopathy. Genetic tests did not reveal any mutation related to hereditary forms of β -amyloid pathology.