A ontogenia da secreção de saliva em lactentes e a proteção pré-epitelial do esôfago

Abstract

Background - Several studies have reported that severe refux esophagitis is rare in infants despite the well known high occurrence of regurgitation in early infancy. There is evidence of the importance of saliva for the pre-epithelial protection of the esophageal mucosa. Results - A longitudinal study conducted on healthy infants indicated that the stimulated capacity of saliva secretion (saliva output per kg of body weight) was significantly higher during their frst year of age compared to older children and adults. In addition, this secretion pattern was also observed in low weight newborns during the frst weeks of life and persisted in infants with severe protein-calorie malnutrition (marasmus). Conclusion - The greater ability to secrete saliva is an important physiological condition that may protect the infant from acid/pepsin aggression to the esophagus during early stages of development.