Longevity Regulation by Insulin/IGF-1 Signalling

Abstract

For the past three decades, many ageing-regulatory pathways have been identified using C. elegans as a model organism. The insulin/insulin- like growth factor (IGF)-1 signalling (IIS) pathway is one of the most evolutionarily well-con- served ageing-regulatory pathways ranging from worms to mammals. Here, we review the molecular mechanism and the functional significance of IIS in C. elegans ageing. Specifically, we describe the roles of key components of IIS in ageing, sys- temic ageing regulation by IIS, and other known physiological functions of IIS that contribute to longevity. We also discuss possible implications of IIS in mammalian health and ageing. Keywords