Lack of association between I/D ACE and -675 ID 4G / 5G PAI-1 polymorphisms and predicting risk of pregnancy loss (PROPALO) in Bosnian women

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Abstract

Successful pregnancies, among others, require stabilization of the placental basal plate, preventing accumulation of fibrin in placental vessels and intervillous spaces. Fibrinolysis is regulated by PAI-1, which synthesis is induced by angiotensin II, which is being generated by ACE I. In recent studies, it was found that -675 ID, 4G/5G PAI-1 gene polymorphism, as referred to “a new thrombophilic factor” may increase risk of pregnancy loss. Data on prevalence of genetic risk factors of thrombophilia in Bosnia and Herzegovina (B&H) are rare. Aim: Therefore, we aimed to determine prevalence of I/D ACE (rs l799752) and -675 ID, 4G/5G PAI-1 (rs 1799889) polymorphisms in Bosnian women with pregnancy loss and evaluate the results of the risk of miscarriages. Material and Methods: We prospectively recruited 308 women in total, particulary 154 women with pregnancy loss (PL), mean age 33.0 (±5.4) years and 154 controls without pregnancy loss, at least one liveborn child, mean age 31.4 (±6.7) years. All women were enrolled from Institution of Health Protection of Women and Motherhood (Sarajevo, B&H). Following DNA isolation from buccal swabs, PCR for ACE and real-time PCR for PAI-1 was performed. Results: In women with PL and controls, the frequencies of D and 4G alleles were: 52.3% and 55.5% and 60.1% and 59.7%, respectively. There was no difference of frequency of mutated alleles in group of PL compared to the controls (p>0.05). Conclusion: Our results, did not confirm association of I/D ACE and -675 ID, 4G/5G PAI-1 polymorphisms with pregnancy loss in examined population.

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Emir, M., Karolina, S. Ż., Amina, V., Nevena, M., Anna, P. M., Ewa, C., … Grażyna, A. (2017). Lack of association between I/D ACE and -675 ID 4G / 5G PAI-1 polymorphisms and predicting risk of pregnancy loss (PROPALO) in Bosnian women. In IFMBE Proceedings (Vol. 62, pp. 440–444). Springer Verlag. https://doi.org/10.1007/978-981-10-4166-2_68

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