Paroxetine efficacy in the treatment of generalized anxiety disorder

204Citations
Citations of this article
56Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Recently, there has been a renewed interest in alternatives to the benzodiazepines for the treatment of generalized anxiety disorder (GAD). The aim of the present study was to compare the efficacy of paroxetine vs. imipramine and 2'-chlordesmethyldiazepam in 81 patients with a DSM-IV diagnosis of GAD. Approximately two-thirds of the patients who completed the study improved greatly or moderately on all three active drugs. During the first 2 weeks of treatment, 2'-chlordesmethyldiazepam treatment resulted in the greatest improvement in anxiety ratings. Both paroxetine and imipramine treatment resulted in more improvement than 2'-chlordesmethyldiazepam by the fourth week of treatment. Paroxetine and imipramine affect predominantly psychic symptoms, whereas 2'-chlordesmethyldiazepam affects predominantly somatic symptoms. Our results suggest that paroxetine is effective for the treatment of GAD.

Cite

CITATION STYLE

APA

Rocca, P., Fonzo, V., Scotta, M., Zanalda, E., & Ravizza, L. (1997). Paroxetine efficacy in the treatment of generalized anxiety disorder. Acta Psychiatrica Scandinavica, 95(5), 444–450. https://doi.org/10.1111/j.1600-0447.1997.tb09660.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free