In less than two decades, activity-based protein profiling (ABPP) has expanded to become the de facto tool for the study of small molecule-protein interactions in a proteomic environment. In this issue, Na et al. (2015) present another ABPP method, which they called reactive probe-based chemical proteomics, to study host-pathogen interaction and subsequently identify the protein PheA as a potential key effector during the pathogen infection process.
Ge, J., & Yao, S. Q. (2015, April 23). Chemical proteomics of host-pathogen interaction. Chemistry and Biology. Elsevier Ltd. https://doi.org/10.1016/j.chembiol.2015.04.002