Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters

Abstract

Background: Recurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. BCR-ABL rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, BCR -ABL - is the commonest recurrent abnormality whereas, IgH rearrangements are rare. Aim: Aim of this study was to identify common recurrent genetic abnormalities in adult B ALL and study their association with hematological findings. Methods: Bone marrow and peripheral blood from patients with B acute lymphoblastic leukemia were analyzed for complete blood counts, bone marrow morphology and cytogenetic abnormalities. The study group was divided into smaller groups based on cytogenetic abnormalities. Hematological parameters and presence of recurrent genetic abnormalities was compared across age groups and gender by non parametric tests. Results: BCR-ABL positive group had a higher leukocyte count than BCR-ABL negative group. Among groups 1 to 5, group 1 with gains of chromosomes was associated with leucopenia and higher age at presentation. BCR-ABL is commonest recurrent abnormality followed by IgH rearrangements. Conclusion: Patients with gains of chromosomes alone have low total leukocyte counts at presentation.