Impact of plasma neutrophil gelatinase-associated lipocaline level on early outcome of a patient with ST-segment elevation myocardial infarction

Abstract

In patients with the atherosclerotic arteries, Neutrophil gelatinase-associated lipocaline (NGAL) may play a part in vascular remodeling and the instability of atherosclerotic plaques. Patients with angiographically documented coronary artery disease have significantly higher levels of serum NGAL compared with persons with normal coronary arteries. This study aims to determine the short term prognostic value of NGAL serum levels in a patient with acute ST-segment elevation myocardial infarction. This is study enrolled twenty patients with acute ST-elevation myocardial infarction (STEMI) and twenty healthy subjects as control. Serum NGAL level was compared between the patients and control and then correlated with early outcome of the patients. There was a significant elevation of serum NGAL in STEMI patients COMARED with control, and significant relationship was observed between admission serum NGAL early complications and mortality. High NGAL level associated with poor outcome in STEMI patients and can be use as initial indicator for close monitoring of high-risk patients.