Improved classification of rheumatoid arthritis with a score including anti-acetylated ornithine antibodies

12Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The presence of rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) autoantibodies contributes to the current rheumatoid arthritis (RA) classification criteria. These criteria involve stratification on antibody levels, which limits reproducibility, and underperform in the RA patients without RF and anti-CCP. Here, we have explored if two anti-acetylated peptide antibodies (AAPA), anti-acetylated lysine (AcLys) and anti-acetylated ornithine (AcOrn), could improve the performance of the current criteria. The analysis was done in 1062 prospectively-followed early arthritis (EA) patients. The anti-AcOrn were more informative than the anti-AcLys, the conventional RA antibodies and the anti-carbamylated protein antibodies. The anti-AcOrn produced a classification that did not require antibody levels and showed improved specificity (77.6% vs. 72.6%, p = 0.003) and accuracy (79.0% vs. 75.8%, p = 0.002) over the current criteria. These improvements were obtained with a scoring system that values concordance between anti-AcOrn, RF and anti-CCP. No significant gain was obtained in sensitivity (80.2% vs. 78.8%, p = 0.25) or in improving the classification of the RA patients lacking RF and anti-CCP, although the anti-AcOrn ranked first among the analysed new antibodies. Therefore, the anti-AcOrn antibodies could contribute to the improvement of RA classification criteria by exploiting antibody concordance.

References Powered by Scopus

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

19363Citations
N/AReaders
Get full text

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

7104Citations
N/AReaders
Get full text

Rheumatoid arthritis

3489Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings

63Citations
N/AReaders
Get full text

Presence of anti-acetylated peptide antibodies (AAPA) in inflammatory arthritis and other rheumatic diseases suggests discriminative diagnostic capacity towards early rheumatoid arthritis

13Citations
N/AReaders
Get full text

Increased risk of rheumatoid arthritis in patients with endometriosis: genetic aspects

12Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Rodriguez-Martínez, L., Bang, H., Regueiro, C., Nuño, L., Triguero-Martinez, A., Peiteado, D., … Gonzalez, A. (2020). Improved classification of rheumatoid arthritis with a score including anti-acetylated ornithine antibodies. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-73919-y

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 6

86%

Researcher 1

14%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 4

40%

Medicine and Dentistry 3

30%

Immunology and Microbiology 2

20%

Nursing and Health Professions 1

10%

Save time finding and organizing research with Mendeley

Sign up for free