Synthesis and reactions of 2,6-bis[3-oxo-3-propanenitrile-2-(N, Ndimethylamino) methylene]pyridine

Abstract

The versatile multifunctional hitherto unreported 2,6-bis-[3-oxo-3- propanenitrile-2-(N,Ndimethylamino) methylene]pyridine 3 was prepared by the reaction of pyridine-2,6-bis-(3-oxo-3- propanenitrile) 2 with dimethylformamide-dimethylacetal (DMF-DMA). Several new pyrazole, isoxazole, pyrimidine, pyrazolopyrimidine, triazolopyrimidine and imidazopyrimidine derivatives have been synthesized by the reactions of 2,6-bis[3-oxo-3- propanenitrile-2-(N,Ndimethylamino) methylene]pyridine 3 with several nitrogen binucleophiles. © ARKAT-USA, Inc.