Analysis of New Biomarkers for the Diagnosis of Polycystic Ovary Syndrome in Adolescents

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine problem with complex diagnosis in adolescents. Therefore, it is important to identify reliable biomarkers that can be used in the diagnosis of PCOS in adolescents. To investigate the diagnostic value of anti-Müllerian hormone (AMH) and inhibin-A (INH-A) and insulin-like peptide-3 (INSL3) in adolescents with PCOS, and to explain the relationship between these hormones and the clinical / laboratory findings of hyperandrogenism. Materials and Methods: Fifty-five girls aged 15-20 years who were diagnosed with PCOS were included in the present study. The control group consisted of healthy adolescents who had regular menstrual cycles for at least two years and were compatible with the study group according to age and body mass index (BMI). The hormonal profile was assessed in the PCOS and control group. Transabdominal pelvic ultrasonography was performed only in the PCOS group. Results: AMH and INH-A levels were found to be significantly higher in the PCOS group than control group. While the INSL3 did not correlate with anthropometric or laboratory parameters, AMH level showed a positive correlation with the WC SDS, waist / hip ratio, FAI, LH, fT and INH-A. Moreover, INH-A level showed a positive correlation with WC SDS, LH, LH / FSH ratio, SHBG and AMH. In receiver-operating characteristic analysis, the cut-off value for AMH for the diagnosis of PCOS in adolescents was 5.8 ng / mL that for INH-A was 9.3 pg/mL (the specificity and sensitivity were 86% and 70% and 66% and 82% respectively). When AMH and INH-A were used in combination, the specificity and sensitivity were 74% and 88%, respectively. Conclusion: INH-A and AMH can be used as new biomarkers for the diagnosis of PCOS in adolescents, while INSL3 has no diagnostic value in this regard.