Nutraceutical strategies for suppressing nlrp3 inflammasome activation: Pertinence to the management of covid-19 and beyond

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Abstract

Inflammasomes are intracellular protein complexes that form in response to a variety of stress signals and that serve to catalyze the proteolytic conversion of pro-interleukin-1β and pro-interleukin-18 to active interleukin-1β and interleukin-18, central mediators of the inflammatory response; inflammasomes can also promote a type of cell death known as pyroptosis. The NLRP3 inflammasome has received the most study and plays an important pathogenic role in a vast range of pathologies associated with inflammation—including atherosclerosis, myocardial infarction, the complications of diabetes, neurological and autoimmune disorders, dry macular degeneration, gout, and the cytokine storm phase of COVID-19. A consideration of the molecular biology underlying inflammasome priming and activation enables the prediction that a range of nutraceuticals may have clinical potential for suppressing inflammasome activity—antioxidants including phycocyanobilin, phase 2 inducers, melatonin, and N-acetylcysteine, the AMPK activator berberine, glucosamine, zinc, and various nutraceuticals that support generation of hydrogen sulfide. Complex nutraceuticals or functional foods featuring a number of these agents may find utility in the prevention and control of a wide range of medical disorders.

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McCarty, M. F., Assanga, S. B. I., Luján, L. L., O’keefe, J. H., & Dinicolantonio, J. J. (2021, January 1). Nutraceutical strategies for suppressing nlrp3 inflammasome activation: Pertinence to the management of covid-19 and beyond. Nutrients. MDPI AG. https://doi.org/10.3390/nu13010047

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