Two respiration-related rhythm generators, the pre-Bötzinger complex inspiratory and the parafacial pre-inspiratory rhythm generators, have been identified in the medulla of rodents that produce intrinsic periodic bursts. Although both generators can be independently active under specific conditions, they interact as a coupled oscillator system to regulate the respiratory rhythm. Here, we summarize different mechanisms of modulation of the respiratory rhythm in the brainstem-spinal cord preparation of newborn rats and discuss factors determining rhythm generator dominance. We show two different modes of respiratory rhythm generation in the brainstem-spinal cord preparation that depends on the background stimulation level. © 2008 Springer Science+Business Media, LLC.
CITATION STYLE
Onimaru, H., & Homma, I. (2008). Two modes of respiratory rhythm generation in the newborn rat brainstem-spinal cord preparation. In Advances in Experimental Medicine and Biology (Vol. 605, pp. 104–108). https://doi.org/10.1007/978-0-387-73693-8_18
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