Seluang (Rasbora agrotyenia) Fish Oil Increases Vitamin D in Autoimmune Patients (Systemic Lupus Erythematosus)

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which usually affects multiple organ systems. Its patients are prone to hypovitaminosis D along with its complications such as osteoporosis. The improvement of vitamin D status in SLE patients is associated with better immune modulation, proinflammatory cytokine suppression, calcium absorption improvement, as well as better severity and lower osteoclastogenesis. This double-blind, randomised clinical trial was conducted in the Allergology-Immunology Polyclinic in the Internal Medicine Department of Mohammad Hoesin General Hospital, Palembang, Indonesia, over the period April 2017 - February 2018. Samples were given either seluang (Rasbora agrotyenia) fish oil or placebo for 12 weeks. On the start and the end of the study, vitamin D levels were examined. 32 patients, all female, were divided evenly into the two groups. On the end of the study, the seluang oil group had significant vitamin D increase compared to placebo (p = 0.000). We concluded that the administration of seluang fish oil was able to increase vitamin D levels in SLE patients.