Antioxidant, Antibacterial and Hypoglycemic Activity of Extracts from Thymelaea microphylla Coss. et Dur.

Abstract

AbstractThe objective of this study was to evaluate different biological activities of aqueous and ethanolic extracts from Thymelaea microphylla. Antioxidant capacity was determined using two methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, and the inhibition of lipid peroxidation using the β-carotene/linoleate model system. Disc diffusion method was used to evaluate the antibacterial activity on four different strains. Hypoglycemic effect of aqueous extract was tested in rats. Aqueous and ethanolic extracts showed a good antioxidant activity with IC50 of 0.1 and 0.2 mg/ml in DPPH test, and RRA% of 46.40% and 77.86% in β-carotene/linoleate assay respectively. Both extracts had no antibacterial effect on studied strains. A single administration of aqueous extract at a dose of 250 mg/kg bodyweight caused a very significant decrease in blood glucose level in rat. Keywords: Antibacterial activity, β-carotene/linoleate, DPPH, Hypoglycemic activity, Thymelaea microphylla Please cite this paper as: Dahamna S, Dehimi K, Merghem M, et al. Antioxidant, antibacterial and hypoglycemic activity of extracts from Thymelaea microphylla Coss. et Dur.