Hypolipidaemic Activity of Methanol Extract of Aleurites moluccana

Abstract

The lipid-low ering action of the leaves of the Aleurites moluccana methanol extract was studied in Triton W-1339 and high-fat-diet fed rats. The serum lipids (total cholesterol, LDL- and HDL-cholesterol and triglycérides) and body weight were found to be lowered by A. moliiccana (300 ing/kg, b.w.) in rats with Triton-induced hypercholestcrolaemia and on a hyperlipaemic diet. The results suggest that the lipid lowering action of this natural product is mediated through inhibition of hepatic cholesterol biosynthesis and reduction of lipid absorption in the intestine. Copyright ©2002 John Wiley & Sons, Ltd.