Abstract
Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.
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CITATION STYLE
APA
Gómez, A. B., Cortés González, M. A., Lübcke, M., Johansson, M. J., Halldin, C., Szabó, K. J., & Schou, M. (2016). Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides. Chemical Communications, 52(97), 13963–13966. https://doi.org/10.1039/c6cc08535k
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