Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.
CITATION STYLE
Furutani, T., Takeyama, K. I., Koutoku, H., Ito, S., Taniguchi, N., Suzuki, E., … Kato, S. (2005). A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line. Bioscience, Biotechnology and Biochemistry, 69(11), 2236–2239. https://doi.org/10.1271/bbb.69.2236
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