Masking MALT1: The paracaspase's potential for cancer therapy

Abstract

A key feature of aggressive B cell lymphomas is constitutive NF-κB activation, which requires signals from the CARD11-BCL-10-MALT1 (CMB) complex. The unique enzymatic activity of MALT1 degrades one of its binding partners, BCL-10, as well as the NF-κB inhibitor A20. New data shows that targeting MALT1 protease activity may be a promising therapeutic strategy for treating aggressive B cell lymphomas. © 2009 Vucic and Dixit.