MicroRNAs in cancer metastasis: Biological and therapeutic implications

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Abstract

Cancer metastasis is the primary cause of cancer-related deaths. The seeding of primary tumours at a secondary site is a highly inefficient process requiring substantial alterations in the genetic architecture of cancer cells. These alterations include significant changes in global gene expression patterns. MicroRNAs are small, non-protein coding RNAs which play a central role in regulating gene expression. Here, we focus on microRNA determinants of cancer metastasis and examine microRNA dysregulation in metastatic cancer cells. We dissect the metastatic process in a step-wise manner and summarise the involvement of microRNAs at each step. We also discuss the advantages and limitations of different microRNA-based strategies that have been used to target metastasis in pre-clinical models. Finally, we highlight current clinical trials that use microRNA-based therapies to target advanced or metastatic tumours.

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Sell, M. C., Ramlogan-Steel, C. A., Steel, J. C., & Dhungel, B. P. (2023, March 17). MicroRNAs in cancer metastasis: Biological and therapeutic implications. Expert Reviews in Molecular Medicine. Cambridge University Press. https://doi.org/10.1017/erm.2023.7

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