Abstract
Background: Adipogenesis is the process by which adipocytes are formed to maintain or expand fat depots. Results: Prostaglandin F2α ethanolamide (PGF2αEA) is produced from anandamide in preadipocytes and inhibits adipogenesis. Conclusion: Conversion of proadipogenic anandamide to antiadipogenic PGF2αEA is a novel mechanism for the regulation of adipogenesis. Significance: Discovering a PGF 2αEA-mediated negative regulatory mechanism over adipogenesis may lead to the development of antiobesity therapies. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Silvestri, C., Martella, A., Poloso, N. J., Piscitelli, F., Capasso, R., Izzo, A., … Di Marzo, V. (2013). Anandamide-derived prostamide F2α negatively regulates adipogenesis. Journal of Biological Chemistry, 288(32), 23307–23321. https://doi.org/10.1074/jbc.M113.489906
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