Validation of Modeling and Simulation Methods in Computational Biology

Abstract

In recent years, a highly sophisticated array of modeling and simulation tools in all areas of biological and biomedical research has been developed. These tools have the potential to provide new insights into biological mechanisms integrating subcellular, cellular, tissue, organ, and potentially whole organism levels. Current research is focused on how to use these methods for translational medical research, such as for disease diagnosis and understanding, as well as drug discovery. In addition, these approaches enhance the ability to use human-derived data and to contribute to the refinement of high-cost experimental-based research. Additionally, the conflicting conceptual frameworks and conceptions of modeling and simulation methods from the broad public of users could have a significant impact on the successful implementation of aforementioned applications. This in turn could result in successful collaborations across academic, clinical, and industrial sectors. To that end, this study provides an overview of the frameworks and disciplines used for validation of computational methodologies in biomedical sciences.