Abstract
During infl ammation and developmental processes, heavy chains (HCs) from inter-α-inhibitor (IαI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG- 6) to form a HC-HA complex. In this manuscript, we describe a gel-based assay to detect HC-HA and TSG-6 activity in tissues.
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APA
Lauer, M. E., Loftis, J., de la Motte, C., & Hascall, V. C. (2015). Analysis of the heavy-chain modifi cation and TSG-6 activity in pathological hyaluronan matrices. Methods in Molecular Biology, 1229, 543–548. https://doi.org/10.1007/978-1-4939-1714-3_42
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