The pharmacokinetics of sufentanil in surgical patients

Abstract

The pharmacokinetics of sufentanil, a new thienyl analogue of fentanyl, were studied in 10 surgical patients. Sufentanil, 5 μg/kg, was given intravenously as a bolus injection and plasma concentrations measured at intervals up to 8 h. Plasma sufentanil concentrations decreased rapidly after injection - 98% of the administered dose having left the plasma within 30 min. In 9 of the 10 patients, a tri-exponential equation optimally described the sufentanil concentration decay curve, with average (±SEM) half-lives for the rapid (π) and slow (α) distribution phases of 1.4 ± 0.3 min and 17.7 ± 2.6 min, respectively. The average terminal elimination (β) half-life was 164 ± 22 min. The average value for Vdβ was 2.9 ± 0.2 l/kg, Vd(ss) 1.7 ± 0.2 l/kg and total plasma clearance 12.7 + 0.8 ml·kg-1·min-1 (935 ± 50 ml/min). In one patient, a biexponential equation was sufficient to describe the concentration-time data, yielding a distribution half-life of 4.7 min and an elimination half-life of 117 min.