In vivo small animal micro-CT using nanoparticle contrast agents

134Citations
Citations of this article
310Readers
Mendeley users who have this article in their library.

Abstract

Computed tomography (CT) is one of the most valuable modalities for in vivo imaging because it is fast, high-resolution, cost-effective, and non-invasive. Moreover, CT is heavily used not only in the clinic (for both diagnostics and treatment planning) but also in preclinical research as micro-CT. Although CT is inherently effective for lung and bone imaging, soft tissue imaging requires the use of contrast agents. For small animal micro-CT, nanoparticle contrast agents are used in order to avoid rapid renal clearance. A variety of nanoparticles have been used for micro-CT imaging, but the majority of research has focused on the use of iodine-containing nanoparticles and gold nanoparticles. Both nanoparticle types can act as highly effective blood pool contrast agents or can be targeted using a wide variety of targeting mechanisms. CT imaging can be further enhanced by adding spectral capabilities to separate multiple co-injected nanoparticles in vivo. Spectral CT, using both energy-integrating and energy-resolving detectors, has been used with multiple contrast agents to enable functional and molecular imaging. This review focuses on new developments for in vivo small animal micro-CT using novel nanoparticle probes applied in preclinical research.

References Powered by Scopus

Practical cone-beam algorithm

5550Citations
N/AReaders
Get full text

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

3535Citations
N/AReaders
Get full text

Nanoparticle PEGylation for imaging and therapy

1793Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Medical Imaging of Microrobots: Toward in Vivo Applications

194Citations
N/AReaders
Get full text

Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography

179Citations
N/AReaders
Get full text

Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography

142Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ashton, J. R., West, J. L., & Badea, C. T. (2015). In vivo small animal micro-CT using nanoparticle contrast agents. Frontiers in Pharmacology. Frontiers Research Foundation. https://doi.org/10.3389/fphar.2015.00256

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 116

63%

Researcher 49

27%

Professor / Associate Prof. 13

7%

Lecturer / Post doc 5

3%

Readers' Discipline

Tooltip

Medicine and Dentistry 41

36%

Engineering 31

27%

Physics and Astronomy 21

18%

Biochemistry, Genetics and Molecular Bi... 21

18%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free