A genome wide pattern of population structure and admixture in peninsular Malaysia Malays

15Citations
Citations of this article
72Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Results: We found evidence of genetic influx from Indians to Malays, more in Melayu Kedah and Melayu Kelantan which are genetically different from the other Malay sub-ethnic groups, but similar to Thai Pattani. More than 98% of these northern Malays haplotypes could be found in either Indians or Chinese populations, indicating a highly admixture pattern among populations. Nevertheless, the ancestry lines of Malays, Indonesians and Thais were traced back to have shared a common ancestor with the Proto-Malays and Chinese. Background: The Malays consist of various sub-ethnic groups which are believed to have different ancestral origins based on their migrations centuries ago. The sub-ethnic groups can be divided based on the region they inhabit; the northern (Melayu Kedah and Melayu Kelantan), western (Melayu Minang) and southern parts (Melayu Bugis and Melayu Jawa) of Peninsular Malaysia. We analyzed 54,794 autosomal single nucleotide polymorphisms (SNPs) which were shared by 472 unrelated individuals from 17 populations to determine the genetic structure and distributions of the ancestral genetic components in five Malay sub-ethnic groups namely Melayu Bugis, Melayu Jawa, Melayu Minang, Melayu Kedah, and Melayu Kelantan. We also have included in the analysis 12 other study populations from Thailand, Indonesia, China, India, Africa and Orang Asli sub-groups in Malay Peninsula, obtained from the Pan Asian SNP Initiative (PASNPI) Consortium and International HapMap project database. Conclusions: These results support genetic admixtures in the Peninsular Malaysia Malay populations and provided valuable information on the enigmatic demographical history as well as shed some insights into the origins of the Malays in the Malay Peninsula.

References Powered by Scopus

Inference of population structure using multilocus genotype data

28518Citations
N/AReaders
Get full text

MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0

26055Citations
N/AReaders
Get full text

Estimating F-statistics for the analysis of population structure.

16025Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The genetic history of Peninsular Malaysia

29Citations
N/AReaders
Get full text

Glucocerebrosidase (GBA) gene variants in a multi-ethnic Asian cohort with Parkinson’s disease: mutational spectrum and clinical features

26Citations
N/AReaders
Get full text

Analysis of selected glutathione S-transferase gene polymorphisms in Malaysian type 2 diabetes mellitus patients with and without cardiovascular disease

15Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Hatin, W. I., Nur-Shafawati, A. R., Etemad, A., Jin, W., Qin, P., Xu, S., … Zhao, G. (2014). A genome wide pattern of population structure and admixture in peninsular Malaysia Malays. HUGO Journal, 8(1), 1–18. https://doi.org/10.1186/s11568-014-0005-z

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 20

53%

Professor / Associate Prof. 6

16%

Lecturer / Post doc 6

16%

Researcher 6

16%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 13

38%

Agricultural and Biological Sciences 11

32%

Medicine and Dentistry 7

21%

Nursing and Health Professions 3

9%

Article Metrics

Tooltip
Mentions
References: 2
Social Media
Shares, Likes & Comments: 172

Save time finding and organizing research with Mendeley

Sign up for free