Introduction

Abstract

Schwann cells have key roles in development, differentiation, physiological homeostasis, and axonal regeneration and remyelination after injury in the peripheral nervous system. The abnormalities of Schwann cells and their crosstalk with neurons lead to peripheral nerve disorders, such as Charcot-Marie-Tooth disease, immune-mediated neuropathy, amyloid polyneuropathy, and diabetic neuropathy. In this book, we summarize recent topics on the biological features of Schwann cells under normal and pathological conditions, and introduce spontaneously immortalized Schwann cell lines from normal adult rodents and murine models of neurodegenerative disorders.