Background: Genome-wide expression patterns in physiological cardiac hypertrophy. Co-expression patterns in physiological cardiac hypertrophy. Results: In this study, the first large-scale analysis of publicly available genome-wide expression data of several in vivo murine models of physiological LVH was carried out using network analysis. On evaluating 3 million gene co-expression patterns across 141 relevant microarray experiments, it was found that physiological adaptation is an evolutionarily conserved processes involving preservation of the function of cytochrome c oxidase, induction of autophagy compatible with cell survival, and coordinated regulation of angiogenesis.Conclusion: This analysis not only identifies known biological pathways involved in physiological LVH, but also offers novel insights into the molecular basis of this phenotype by identifying key networks of co-expressed genes, as well as their topological and functional properties, using relevant high-quality microarray experiments and network inference. © 2010 Drozdov et al; licensee BioMed Central Ltd.
CITATION STYLE
Drozdov, I., Tsoka, S., Ouzounis, C. A., & Shah, A. M. (2010). Genome-wide expression patterns in physiological cardiac hypertrophy. BMC Genomics, 11(1). https://doi.org/10.1186/1471-2164-11-557
Mendeley helps you to discover research relevant for your work.