Regulation of B cell growth and differentiation via CD21 and CD40

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Abstract

Stimulation in vitro of murine splenic B cells by lipopolysaccharide, anti-κ Sepharose, anti-CD40 or allo-reactive T helper cells all up-regulated CD21 and CD23 surface expression. Neither anti-CD21 nor anti-CD23 antibodies induced B cell growth or differentiation when added in soluble form or coupled to Sepharose. However, anti-CD40-stimulated B cells showed increased proliferation in the presence of anti-CD21 antibodies coupled to Sepharose; co-stimulation via CD21 also induced differentiation to immunoglobulin secretion in a fraction of anti-CD40-stimulated B cells. Furthermore, anti-CD40 antibodies inhibited differentiation to immunoglobulin secretion induced by lipopolysaccharide and, hence, appears to be a dominant negative signal for B cell differentiation.

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Axcrona, K., Gray, D., & Leanderson, T. (1996). Regulation of B cell growth and differentiation via CD21 and CD40. European Journal of Immunology, 26(9), 2203–2207. https://doi.org/10.1002/eji.1830260936

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