Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.
CITATION STYLE
Käsmann, L., Dietrich, A., Staab-Weijnitz, C. A., Manapov, F., Behr, J., Rimner, A., … Belka, C. (2020, September 10). Radiation-induced lung toxicity - Cellular and molecular mechanisms of pathogenesis, management, and literature review. Radiation Oncology. BioMed Central Ltd. https://doi.org/10.1186/s13014-020-01654-9
Mendeley helps you to discover research relevant for your work.