Sensitivity to White Matter fMRI Activation Increases with Field Strength

42Citations
Citations of this article
54Readers
Mendeley users who have this article in their library.

Abstract

Functional magnetic resonance imaging (fMRI) activation in white matter is controversial. Given that many of the studies that report fMRI activation in white matter used high field MRI systems, we investigated the field strength dependence of sensitivity to white matter fMRI activation. In addition, we evaluated the temporal signal to noise ratio (tSNR) of the different tissue types as a function of field strength. Data were acquired during a motor task (finger tapping) at 1.5 T and 4 T. Group and individual level activation results were considered in both the sensorimotor cortex and the posterior limb of the internal capsule. We found that sensitivity increases associated with field strength were greater for white matter than gray matter. The analysis of tSNR suggested that white matter might be less susceptible to increases in physiological noise related to increased field strength. We therefore conclude that high field MRI may be particularly advantageous for fMRI studies aimed at investigating activation in both gray and white matter. © 2013 Mazerolle et al.

Cite

CITATION STYLE

APA

Mazerolle, E. L., Gawryluk, J. R., Dillen, K. N. H., Patterson, S. A., Feindel, K. W., Beyea, S. D., … D’Arcy, R. C. N. (2013). Sensitivity to White Matter fMRI Activation Increases with Field Strength. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0058130

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free