Abstract
The effect of age on human striatal dopamine D2 receptors was investigated with positron emission tomography (PET) using [11C]raclopride as a radioligand. Twenty-one healthy volunteers aged from 20 to 81 years were studied. An equilibrium method was applied and two separate PET scans with different specific activities of [11C]raclopride were performed. The maximal number of receptors (Bmax) and their dissociation constant (Kd) were calculated using Scatchard analysis. There was an age-dependent decline in the Bmax (r = -0.49; p = of striatal D2 receptors while the Kd remained unchanged. The results show that there is an age-related loss of atal D2 receptors, which, together with other changes the brain nigrostriatal dopaminergic system, may countinute to extrapyramidal symptoms associated with organisation.
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Rinne, J. O., Hietala, J., Ruotsalainen, U., Säkö, E., Laihinen, A., Någren, K., … Syvälahti, E. (1993). Decrease in human striatal dopamine D2 receptor density with age: A PET study with [11C]raclopride. Journal of Cerebral Blood Flow and Metabolism, 13(2), 310–314. https://doi.org/10.1038/jcbfm.1993.39
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