The pathogenesis and prevention of corneal graft melting after keratoplasty.

Abstract

Keratoplasty is one of the most important treatments of corneal disease. Corneal graft melting is a severe complication that may occur in various types of keratoplasy. With various biomaterials and synthetic materials as substitutes for alternative corneal allograft donors being used in the clinic, there is a rising trend towards corneal graft melting after keratoplasy with these new materials. Corneal graft melting can be caused by many reasons. The review summarizes literature on the incidence, pathogenesis and prognosis of corneal graft melting after keratoplasty. Our results may help to develop suitable management to prevent corneal graft melting, and improve the outcomes of keratoplasty.