Massive Pulmonary Embolism and Thrombolytic Therapy: Case Study

Abstract

Acute pulmonary embolism is the third most common acute cardiovascular disease, with about 600,000 cases annually in the United States. Pulmonary embolism requires a multimodality diagnosis and immediate treatment. Although computed tomography and ventilation perfusion scans are the most commonly used modalities to diagnose pulmonary embolisms, many supplemental tests are necessary. Treatment options for pulmonary embolism include anticoagulation therapy, thrombolytic therapy, or insertion of an inferior vena cava filter when anticoagulation is contraindicated. The long-term benefits of thrombolytic therapy have made it an increasingly popular option in many institutions. The following case study describes a patient who presented to the hospital with shortness of breath for five months and was found to have extensive pulmonary embolisms upon admission. The patient underwent three days of thrombolytic therapy that significantly reduced his pulmonary arterial pressures and resulted in an almost complete resolution of his pulmonary embolisms.