Antisense technology

Abstract

Diseases are often connected to the insufficient or excess production of certain "Proteins". If the production of these proteins is disputed many diseases can be treated or cured. Antisense technology is a method that can dispute protein production. It may be used to design new therapeutics for diseases in whose pathology the production of a specific protein plays a circle role. Antisense technology is a tool that is used for the Inhibition of gene expression. The principle behind it is that an antisense nucleic acid sequence base pairs with its complementary sense RNA strand and prevents it from being translated into a protein. The complimentary nucleic acid sequence can be either a synthetic oligonucleotide, often oligodeoxy ribonucleotides (ODN) of less than 30 nucleotides, or longer antisense RNA (aRNA) sequences. An example of sense and antisense RNA is: 5'ACGU3'mRNA and 3' UGCA5' Antisense RNA. This article gives brief introduction regarding the antisense technology.