Synthesis of Pyrazolines by Cascade Oxidation/Halogenoamino-cyclization Reaction of Homoallylhydrazides

Abstract

An efficient cascade oxidation/halogenoaminocyclization reaction of homoallylhydrazides with N-halogensuc-cinimide was developed without addition of other additives under mild reaction conditions to provide pyrazolines. Under the optimized conditions, a variety of highly substituted pyrazoline derivatives were obtained.