Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers

23Citations
Citations of this article
69Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Characterizing the circulation of Mayaro virus (MAYV), an emerging arbovirus threat, is essential for risk assessment but challenging due to cross-reactivity with other alphaviruses such as chikungunya virus (CHIKV). Here, we develop an analytical framework to jointly assess MAYV epidemiology and the extent of cross-reactivity with CHIKV from serological data collected throughout French Guiana (N = 2697). We find strong evidence of an important sylvatic cycle for MAYV with most infections occurring near the natural reservoir in rural areas and in individuals more likely to go to the forest (i.e., adult males) and with seroprevalences of up to 18% in some areas. These findings highlight the need to strengthen MAYV surveillance in the region and showcase how modeling can improve interpretation of cross-reacting assays.

Cite

CITATION STYLE

APA

Hozé, N., Salje, H., Rousset, D., Fritzell, C., Vanhomwegen, J., Bailly, S., … Cauchemez, S. (2020). Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-16516-x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free