Fear memory recall potentiates opiate reward sensitivity through dissociable dopamine D1 versus D4 receptor-dependent memory mechanisms in the prefrontal cortex

16Citations
Citations of this article
65Readers
Mendeley users who have this article in their library.

Abstract

Disturbances in prefrontal cortical (PFC) dopamine (DA) transmission are well established features of psychiatric disorders involving pathological memory processing, such as post-traumatic stress disorder and opioid addiction. Transmission through PFC DA D4 receptors (D4Rs) has been shown to potentiate the emotional salience of normally nonsalient emotional memories, whereas transmission through PFC DA D1 receptors (D1Rs) has been demonstrated to selectively block recall of reward- or aversion-related associative memories. In the present study, using a combination of fear conditioning and opiate reward conditioning in male rats, we examined the role of PFC D4/D1R signaling during the processing of fear-related memory acquisition and recall and subsequent sensitivity to opiate reward memory formation. We report that PFC D4R activation potentiates the salience of normally subthreshold fear conditioning memory cues and simultaneously potentiates the rewarding effects of systemic or intra-ventral tegmental area (VTA) morphine conditioning cues. In contrast, blocking the recall of salient fear memories with intra-PFC D1R activation, blocks the ability of fear memory recall to potentiate systemic or intra-VTA morphine place preference. These effects were dependent upon dissociable PFC phosphorylation states involving calcium-calmodulin-kinase II or extracellular signal-related kinase 1–2, following intra-PFC D4 orD1Ractivation, respectively. Together, these findings reveal new insights into how aberrant PFC DAergic transmission and associated downstream molecular signaling pathways may modulate fear-related emotional memory processing and concomitantly increase opioid addiction vulnerability.

References Powered by Scopus

Stress-induced relapse to heroin and cocaine seeking in rats: A review

595Citations
N/AReaders
Get full text

Neural dysregulation in posttraumatic stress disorder: Evidence for disrupted equilibrium between salience and default mode brain networks

339Citations
N/AReaders
Get full text

A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D <inf>4</inf> receptor-dependent basolateral amygdala input

195Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish

25Citations
N/AReaders
Get full text

Computational Modeling of Catecholamines Dysfunction in Alzheimer's Disease at Pre-Plaque Stage

21Citations
N/AReaders
Get full text

Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission

20Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Li, J. J., Szkudlarek, H., Renard, J., Hudson, R., Rushlow, W., & Laviolette, S. R. (2018). Fear memory recall potentiates opiate reward sensitivity through dissociable dopamine D1 versus D4 receptor-dependent memory mechanisms in the prefrontal cortex. Journal of Neuroscience, 38(19), 4543–4555. https://doi.org/10.1523/JNEUROSCI.3113-17.2018

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 21

54%

Researcher 9

23%

Professor / Associate Prof. 8

21%

Lecturer / Post doc 1

3%

Readers' Discipline

Tooltip

Neuroscience 26

57%

Psychology 11

24%

Medicine and Dentistry 7

15%

Agricultural and Biological Sciences 2

4%

Article Metrics

Tooltip
Mentions
News Mentions: 6
Social Media
Shares, Likes & Comments: 26

Save time finding and organizing research with Mendeley

Sign up for free