Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?

N/ACitations
Citations of this article
31Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Transverse (t)-tubules are invaginations of the plasma membrane that form a complex network of ducts, 200–400 nm in diameter depending on the animal species, that penetrates deep within the cardiac myocyte, where they facilitate a fast and synchronous contraction across the entire cell volume. There is now a large body of evidence in animal models and humans demonstrating that pathological distortion of the t-tubule structure has a causative role in the loss of myocyte contractility that underpins many forms of heart failure. Investigations into the molecular mechanisms of pathological t-tubule remodelling to date have focused on proteins residing in the intracellular aspect of t-tubule membrane that form linkages between the membrane and myocyte cytoskeleton. In this review, we shed light on the mechanisms of t-tubule remodelling which are not limited to the intracellular side. Our recent data have demonstrated that collagen is an integral part of the t-tubule network and that it increases within the tubules in heart failure, suggesting that a fibrotic mechanism could drive cardiac junctional remodelling. We examine the evidence that the linkages between the extracellular matrix, t-tubule membrane and cellular cytoskeleton should be considered as a whole when investigating the mechanisms of t-tubule pathology in the failing heart.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Crossman, D. J., Jayasinghe, I. D., & Soeller, C. (2017, December 1). Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma? Biophysical Reviews. Springer Verlag. https://doi.org/10.1007/s12551-017-0273-7

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 15

68%

Researcher 4

18%

Lecturer / Post doc 2

9%

Professor / Associate Prof. 1

5%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 6

35%

Biochemistry, Genetics and Molecular Bi... 6

35%

Medicine and Dentistry 4

24%

Philosophy 1

6%

Save time finding and organizing research with Mendeley

Sign up for free