Factors Affecting Iron Absorption and Mitigation Mechanisms: A review

Abstract

Iron has many special functions in the body. More than 65 percent of the body's iron is in the blood in the form of hemoglobin, which is a protein in red blood cells that transports oxygen to tissues in the body. A compound that carries oxygen to the muscle cells called myoglobin, also requires iron. In addition, iron has a role in many chemical reactions within the body that generate energy. A human body can store excess iron as a reserve. The World Health Organization reported that iron defi ciency anemia is one of the most widespread nutrient defi ciencies in the globe. Diverse factors may affect its absorption like low dietary intake of iron, deprived iron absorption, or too much blood loss. Moreover, polyphenolic compounds widely found in coffee and tea such as chlorogenic acids, monomeric fl avonoids, and polyphenol polymerization products also strongly inhibit dietary nonheme-iron absorption. Children, adolescents, pregnant women, women of child-bearing age, athletes, and older adults are groups at greater risk for iron defi ciency. The objective of this review paper is to review factors infl uencing iron absorption.