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Expression of the dengue virus type 2 NS5 protein in a CD4+ T cell line inhibits HIV replication

Journal of Infectious Diseases (2008) 198(6) 860-863
DOI: 10.1086/591254
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Abstract

Human immunodeficiency virus (HIV) load is suppressed during dengue virus infection. The NS5A phosphoprotein of GB virus C (a related flavivirus) inhibits HIV replication in vitro. To determine whether the dengue virus NS5 protein inhibits HIV replication, CD4+ T cell lines expressing this protein were generated. HIV replication in dengue virus NS5-expressing cells decreased by >90% compared with control cells (P

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McLinden, J. H., Stapleton, J. T., Chang, Q., & Xiang, J. (2008). Expression of the dengue virus type 2 NS5 protein in a CD4+ T cell line inhibits HIV replication. Journal of Infectious Diseases, 198(6), 860–863. https://doi.org/10.1086/591254

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