Notch Signaling Pathway in Carcinogenesis

Abstract

The Notch signaling pathway Notch signaling pathway is a highly conserved pathway in most multicellular organisms. It is of critical importance for cell proliferation, differentiation, and homeostasis. Aberrant Notch signaling can give rise to a number of pathologies including cancer. The Notch signaling pathway consists of a well-orchestrated series of biochemical events that provide multiple avenues for rational drug design. Design of targeted therapies focusing on Notch signaling is rapidly advancing. This review will aim to discuss the established and recent approaches to targeting the Notch pathway.