FORMULATION OF SODIUM ASCORBYL PHOSPHATE (SAP) INTO O/W NANOEMULSION

Abstract

Objective: Wrinkles are a natural aging consequence that are most visible on sun-exposed skin, such as the face, neck, hands, and forearms. To meet the demands of the aesthetic market, anti-wrinkle active substances have been produced. Due to its capacity to shield skin from free radicals and promote collagen activity, water-soluble vitamin c has emerged as one of the essential anti-wrinkle options. Vitamin c as an antioxidant, can reduce damage caused by free radicals. Methods: The aim of this study was to develop a water-soluble vitamin c nanoemulsion, identify the optimum formulation, and do stability tests. The method is to mix the ingredients with the same phase first, then mix the two and stabilize with surfactant. A standard procedure was used to produce the nanoemulsion, with the variation ratio of tween 80 to PEG 400 and glycerin. Then, the research went on to the evaluation involved a physical stability test utilizing centrifugation at 3375 rpm, six cycles of freeze-thaw and a thermal stability test at three distinct temperatures for four weeks. Results: The results showed that the 10% glycerin increased SAP's solubility in the oil phase. A clear and transparent nanoemulsion with fine physical and thermal stability and globule sizes less than 200 nm was produced by the optimum formula, which contained Tween 80, PEG 40, glycerin, VCO, and phosphate buffer at pH 6 in a ratio of 17:9:10:3:61. Conclusion: The formulation of Sodium Ascorbyl Phosphate has the good physical, chemical characteristic, and stability properties that makes it acceptable to use it as the primary or supplemental therapy for an anti-wrinkle agent with good efficacy and low side effects.