Role of Nicotinamide in Streptozotocin Induced Diabetes in Animal Models

Abstract

Diabetes mellitus (DM) is a metabolic disease with abnormal glucose homeostasis, due to defects in secretion or action of insulin. It is a potentially morbid condition with high prevalence worldwide and has become a major medical concern. Animal models play an important role in understanding such type of diseases. Diabetes in experimental animal develops either spontaneously or by using chemical, surgical, genetic or other techniques, and depicts many clinical features or related phenotypes of the disease. Streptozotocin (STZ) is a widely used chemical for the induction of experimental diabetes in animals. In this review, we have provided the evidences related to the fact that Nicotinamide play a protective role against destruction of pancreatic β- cells in STZ induced diabetes model in experimental animals.. Keywords: Diabetes mellitus; STZ; Nicotinamide